Published onDecember 28, 2025Painful Periods During Perimenopause: Understanding Menstrual Changes in Your 40s and 50sPainful-PeriodsPerimenopauseMenopauseMenstrual-HealthHormonal-ChangesPerimenopause brings hormonal shifts that can cause increasingly painful periods. Learn why your periods change in your 40s and 50s, and when pain warrants medical attention.